Table of Contents
Cardiovascular Psychiatry and Neurology
Volume 2011 (2011), Article ID 723434, 7 pages
http://dx.doi.org/10.1155/2011/723434
Clinical Study

Diabetic Peripheral Microvascular Complications: Relationship to Cognitive Function

1Institute of Postgraduate Medicine, Brighton and Sussex Medical School, Falmer, Brighton BN1 9PH, UK
2Research Design Service, South West, Royal Devon & Exeter Hospital, Exeter EX2 5DW, Devon, UK
3Cognitive Treatment & Research Unit, Sussex Partnership NHS Foundation Trust, Crowborough, E. Sussex TN6 1NY, UK

Received 20 July 2011; Revised 18 September 2011; Accepted 28 September 2011

Academic Editor: Deborah Mash

Copyright © 2011 Lorraine Ba-Tin et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. P. Zimmet, “The burden of type 2 diabetes: are we doing enough?” Diabetes and Metabolism, vol. 29, no. 4, pp. S9–S18, 2003. View at Google Scholar · View at Scopus
  2. C. Qiu, M. F. Cotch, S. Sigurdsson et al., “Retinal and cerebral microvascular signs and diabetes the age, gene/environment susceptibility-reykjavik study,” Diabetes, vol. 57, no. 6, pp. 1645–1650, 2008. View at Publisher · View at Google Scholar · View at Scopus
  3. S. Y. Yuan, J. W. Breslin, R. Perrin et al., “Microvascular permeability in diabetes and insulin resistance,” Microcirculation, vol. 14, no. 4-5, pp. 363–373, 2007. View at Publisher · View at Google Scholar · View at Scopus
  4. R. O. Roberts, Y. E. Geda, D. S. Knopman et al., “Association of duration and severity of diabetes mellitus with mild cognitive impairment,” Archives of Neurology, vol. 65, no. 8, pp. 1066–1073, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. F. Irie, A. L. Fitzpatrick, and O. L. Lopez, “Enhanced risk factors for Alzheimer’s disease in persons with type 2 diabetes and APOE epsilon4. The Cardiovascular Health Study Cognition Study,” Archives of Neurology, vol. 65, pp. 89–93, 2008. View at Google Scholar
  6. J. A. Luchsinger, C. Reitz, B. Patel, M. X. Tang, J. J. Manly, and R. Mayeux, “Relation of diabetes to mild cognitive impairment,” Archives of Neurology, vol. 64, no. 4, pp. 570–575, 2007. View at Google Scholar · View at Scopus
  7. W. Xu, C. Qiu, B. Winblad, and L. Fratiglioni, “The effect of borderline diabetes on the risk of dementia and Alzheimer's disease,” Diabetes, vol. 56, no. 1, pp. 211–216, 2007. View at Publisher · View at Google Scholar · View at Scopus
  8. A. Akomolafe, A. Beiser, J. B. Meigs et al., “Diabetes mellitus and risk of developing Alzheimer disease: results from the Framingham study,” Archives of Neurology, vol. 63, no. 11, pp. 1551–1555, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. E. S. C. Korf, L. R. White, P. H. Scheltens, and L. J. Launer, “Brain aging in very old men with type 2 diabetes: The Honolulu-Asia Aging Study,” Diabetes Care, vol. 29, no. 10, pp. 2268–2274, 2006. View at Publisher · View at Google Scholar · View at Scopus
  10. L. B. Hassing, S. M. Hofer, S. E. Nilsson et al., “Comorbid type 2 diabetes mellitus and hypertension exacerbates cognitive decline: evidence from a longitudinal study,” Age and Ageing, vol. 33, no. 4, pp. 355–361, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. R. S. Tilvis, M. H. Kähönen-Väre, J. Jolkkonen, J. Valvanne, K. H. Pitkala, and T. E. Strandberg, “Predictors of cognitive decline and mortality of aged people over a 10-year period,” Journals of Gerontology Series A, vol. 59, no. 3, pp. 268–274, 2004. View at Google Scholar · View at Scopus
  12. J. A. Sonnen, E. B. Larson, K. Brickell et al., “Different patterns of cerebral injury in dementia with or without diabetes,” Archives of Neurology, vol. 66, no. 3, pp. 315–322, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. W. Xu, C. Qiu, M. Gatz, N. L. Pedersen, B. Johansson, and L. Fratiglioni, “Mid- And late-life diabetes in relation to the risk of dementia: a population-based twin study,” Diabetes, vol. 58, no. 1, pp. 71–77, 2009. View at Publisher · View at Google Scholar · View at Scopus
  14. J. D. Huber, “Diabetes, cognitive function, and the blood-brain barrier,” Current Pharmaceutical Design, vol. 14, no. 16, pp. 1594–1600, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. S. C. Ferguson, A. Blane, P. Perros et al., “Cognitive ability and brain structure in type 1 diabetes: relation to microangiopathy and preceding severe hypoglycemia,” Diabetes, vol. 52, no. 1, pp. 149–156, 2003. View at Publisher · View at Google Scholar · View at Scopus
  16. N. Patton, T. Aslam, T. MacGillivray, A. Pattie, I. J. Deary, and B. Dhillon, “Retinal vascular image analysis as a potential screening tool for cerebrovascular disease: a rationale based on homology between cerebral and retinal microvasculatures,” Journal of Anatomy, vol. 206, no. 4, pp. 319–348, 2005. View at Publisher · View at Google Scholar · View at Scopus
  17. V. I. Kwa, J. J. van der Sande, J. Stam, N. Tijmes, and J. L. Vrooland, “Retinal arterial changes correlate with cerebral small-vessel disease,” Neurology, vol. 59, pp. 1536–1540, 2002. View at Google Scholar
  18. T. Y. Wong, T. H. Mosley Jr., and R. Klein, “Atherosclerosis Risk in Communities Study. Retinal microvascular changes and MRI signs of cerebral atrophy in healthy, middle-aged people,” Neurology, vol. 61, pp. 806–811, 2003. View at Google Scholar
  19. S. Vupputuri, D. A. Shoham, S. L. Hogan, and A. V. Kshirsagar, “Microalbuminuria, peripheral artery disease, and cognitive function,” Kidney International, vol. 73, no. 3, pp. 341–346, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. A. J. Sinclair, A. J. Girling, and A. J. Bayer, “Cognitive dysfunction in older subjects with diabetes mellitus: impact on diabetes self-management and use of care services. All Wales Research into Elderly (AWARE) Study,” Diabetes Research and Clinical Practice, vol. 50, pp. 203–212, 2000. View at Google Scholar
  21. A. J. Bayer, J. Johnston, and A. J. Sinclair, “Impact of dementia on diabetic care in the aged,” Journal of the Royal Society of Medicine, vol. 87, no. 10, pp. 619–621, 1994. View at Google Scholar · View at Scopus
  22. P. J. Fray, T. W. Robbins, and B. J. Sahakian, “Neuorpsychiatyric applications of CANTAB,” International Journal of Geriatric Psychiatry, vol. 11, no. 4, pp. 329–336, 1996. View at Publisher · View at Google Scholar · View at Scopus
  23. J. Greene, Learning to Use Statistical Tests in Psychology, The Open University Press, 2nd edition, 1999.
  24. W. J. Conover and R. L. Iman, “Analysis of covariance using the rank transformation,” Biometrics, vol. 38, no. 3, pp. 715–724, 1982. View at Google Scholar · View at Scopus
  25. C. DeCarli, D. G. Murphy, M. Tranh et al., “The effect of white matter hyperintensity volume on brain structure, cognitive performance, and cerebral metabolism of glucose in 51 healthy adults,” Neurology, vol. 45, no. 11, pp. 2077–2084, 1995. View at Google Scholar · View at Scopus
  26. N. Tabet, R. Quinn, and A. Klugman, “Prevalence and cognitive impact of cerebrovascular findings in Alzheimer's disease: a retrospective, naturalistic study,” International Journal of Clinical Practice, vol. 63, no. 2, pp. 338–345, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. M. N. Haan, “Therapy insight: type 2 diabetes mellitus and the risk of late-onset Alzheimer's disease,” Nature Clinical Practice Neurology, vol. 2, no. 3, pp. 159–166, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. G. J. Biessels, I. J. Deary, and C. M. Ryan, “Cognition and diabetes: a lifespan perspective,” The Lancet Neurology, vol. 7, no. 2, pp. 184–190, 2008. View at Publisher · View at Google Scholar · View at Scopus
  29. E. S. C. Korf, E. C. W. Van Straaten, F. E. De Leeuw et al., “Diabetes mellitus, hypertension and medial temporal lobe atrophy: the LADIS study,” Diabetic Medicine, vol. 24, no. 2, pp. 166–171, 2007. View at Publisher · View at Google Scholar · View at Scopus
  30. N. Sasaki, R. Fukatsu, K. Tsuzuki et al., “Advanced glycation end products in Alzheimer's disease and other neurodegenerative diseases,” American Journal of Pathology, vol. 153, no. 4, pp. 1149–1155, 1998. View at Google Scholar · View at Scopus
  31. M. A. Fishel, G. S. Watson, T. J. Montine et al., “Hyperinsulinemia provokes synchronous increases in central inflammation and β-amyloid in normal adults,” Archives of Neurology, vol. 62, no. 10, pp. 1539–1544, 2005. View at Publisher · View at Google Scholar · View at Scopus
  32. G. J. Biessels, L. J. Kappelle, and Utrecht Diabetic Encephalopathy Study Group, “Increased risk of Alzheimer's disease in Type II diabetes: insulin resistance of the brain or insulin-induced amyloid pathology?” Biochemical Society Transactions, vol. 33, pp. 1041–1044, 2005. View at Google Scholar
  33. W. Q. Qiu and M. F. Folstein, “Insulin, insulin-degrading enzyme and amyloid-β peptide in Alzheimer's disease: review and hypothesis,” Neurobiology of Aging, vol. 27, no. 2, pp. 190–198, 2006. View at Publisher · View at Google Scholar · View at Scopus
  34. M. Lesort and G. V. W. Johnson, “Insulin-like growth factor-1 and insulin mediate transient site-selective increases in tau phosphorylation in primary cortical neurons,” Neuroscience, vol. 99, no. 2, pp. 305–316, 2000. View at Publisher · View at Google Scholar · View at Scopus
  35. R. P. Kloppenborg, E. van den Berg, L. J. Kappelle, and G. J. Biessels, “Diabetes and other vascular risk factors for dementia: which factor matters most? A systematic review,” European Journal of Pharmacology, vol. 585, no. 1, pp. 97–108, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. A. M. A. Brands, G. J. Biessels, E. H. F. De Haan, L. J. Kappelle, and R. P. C. Kessels, “The effects of type 1 diabetes on cognitive performance: a meta-analysis,” Diabetes Care, vol. 28, no. 3, pp. 726–735, 2005. View at Publisher · View at Google Scholar · View at Scopus
  37. N. Awad, M. Gagnon, and C. Messier, “The relationship between impaired glucose tolerance, type 2 diabetes, and cognitive function,” Journal of Clinical and Experimental Neuropsychology, vol. 26, no. 8, pp. 1044–1080, 2004. View at Publisher · View at Google Scholar · View at Scopus
  38. M. W. J. Strachan, I. J. Deary, F. M. E. Ewing, and B. M. Frier, “Is type II diabetes associated with an increased risk of cognitive dysfunction? A critical review of published studies,” Diabetes Care, vol. 20, no. 3, pp. 438–445, 1997. View at Google Scholar · View at Scopus
  39. R. Peila, B. L. Rodriguez, and L. J. Launer, “Type 2 diabetes, APOE gene, and the risk for dementia and related pathologies: the Honolulu-Asia Aging Study,” Diabetes, vol. 51, no. 4, pp. 1256–1262, 2002. View at Google Scholar · View at Scopus
  40. T. Cukierman-Yaffe, H. C. Gerstein, J. D. Williamson et al., “Relationship between baseline glycemic control and cognitive function in individuals with type 2 diabetes and other cardiovascular rIsk factors the action to control cardiovascular risk in diabetes-memory in diabetes (ACCORD-MIND) trial,” Diabetes Care, vol. 32, no. 2, pp. 221–226, 2009. View at Publisher · View at Google Scholar · View at Scopus
  41. H. M. Hodkinson, “Evaluation of a mental test score for assessment of mental impairment in the elderly,” Age and Ageing, vol. 1, no. 4, pp. 233–238, 1972. View at Publisher · View at Google Scholar · View at Scopus
  42. M. F. Folstein, S. E. Folstein, and P. R. McHugh, ““Mini mental state”. A practical method for grading the cognitive state of patients for the clinician,” Journal of Psychiatric Research, vol. 12, no. 3, pp. 789–798, 1975. View at Google Scholar