Risk of Mortality (Including Sudden Cardiac Death) and Major Cardiovascular Events in Atypical and Typical Antipsychotic Users: A Study with the General Practice Research Database
Table 7
Causes of death categorised according to ICD-10 chapter in current users of typical and atypical antipsychotics.
Class
Atypical
Typical
Events (, %)
Incidence rate per 1000 person-years (95% CI)
Events (, %)
Incidence rate per 1000 person-years (95% CI)
A00-B99: certain infectious and parasitic diseases
63 [0.9]
1.98 (1.52–2.53)
46 [0.5]
1.41 (1.03–1.89)
C00-D89: neoplasms/diseases of the blood and blood forming organs and certain disorders involving the immune mechanism
585 [8.2]
1.68 (1.55–1.83)
3955 [43.1]
4.83 (4.68–4.98)
E00-E90: endocrine, nutritional, and metabolic disorders
114 [1.6]
1.50 (1.24–1.80)
106 [1.2]
1.75 (1.43–2.12)
F00-F99: mental and behavioural disorders
907 [12.7]
1.45 (1.36–1.55)
607 [6.6]
1.49 (1.37–1.61)
G00-G99: diseases of the nervous system
657 [9.2]
1.37 (1.27–1.48)
384 [4.2]
1.41 (1.27–1.55)
I00-I99: diseases of the circulatory system
2119 [29.6]
1.66 (1.59–1.73)
1755 [19.1]
1.72 (1.64–1.81)
I20-I25: ischemic heart disease
670 [9.4]
1.59 (1.48–1.72)
570 [6.2]
1.57 (1.44–1.70)
I50: heart failure
108 [1.5]
1.71 (1.40–2.07)
94 [1.0]
2.11 (1.70–2.58)
J00-J99: diseases of the respiratory system
924 [12.9]
1.52 (1.42–1.62)
819 [8.9]
1.57 (1.46–1.68)
K00-K93: diseases of the digestive system
212 [3.0]
1.33 (1.15–1.52)
191 [2.1]
1.40 (1.21–1.61)
L00-L99: diseases of the skin and subcutaneous tissue
20 [0.3]
2.78 (1.70–4.30)
18 [0.2]
1.22 (0.72–1.93)
M00-M99: diseases of the musculoskeletal system and connective tissue
44 [0.6]
1.83 (1.33–2.45)
34 [0.4]
1.90 (1.32–2.66)
N00-N99: disease of the genitourinary system
183 [2.6]
1.51 (1.30–1.74)
162 [1.8]
1.67 (1.42–1.94)
Q00-Q99: congenital malformations, deformations, and chromosomal abnormalities
8 [0.1]
2.04 (0.88–4.02)
8 [0.1]
2.13 (0.92–4.19)
R00-R99: symptoms, signs, and abnormal clinical and laboratory findings
264 [3.7]
1.58 (1.40–1.79)
265 [2.9]
2.08 (1.83–2.34)
V01-Y98: external causes of morbidity and mortality
