Table of Contents
Cardiovascular Psychiatry and Neurology
Volume 2014, Article ID 170626, 4 pages
Research Article

Gamma-Glutamyl Transferase Levels in Patients with Acute Ischemic Stroke

Department of Neurology, FSM Teaching and Research Hospital, E-5 Uzeri, Bostanci, 34744 Istanbul, Turkey

Received 19 June 2014; Revised 4 August 2014; Accepted 8 August 2014; Published 18 August 2014

Academic Editor: Janusz K. Rybakowski

Copyright © 2014 Nurbanu Gurbuzer et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Objective. The aim of this study was to investigate the relationship between gamma-glutamyl transferase (GGT) levels, cerebrovascular risk factors, and distribution of cerebral infarct areas in patients with acute ischemic stroke (AIS). Patients and Methods. Sixty patients with AIS and 44 controls who had not cerebrovascular disease were included in the study. The patients were divided into four groups according to the location of the infarct area and evaluated as for GGT levels and the presence of diabetes mellitus (DM), hypertension (HT), and hyperlipidemia (HL). Results. The frequency of DM, HT, and HL and gender distributions were similar. The mean GGT levels were significantly higher in patients with AIS and those with relatively larger areas of infarction (). Increased mean GGT levels were found in the subgroup with hypertension, higher LDL-cholesterol, and triglyceride levels among cases with AIS (). Conclusion. Higher GGT levels in AIS patients reinforce the relationship of GGT with inflammation and oxidative stress. The observation of higher GGT levels in patients with relatively larger areas of infarction is indicative of a positive correlation between increases in infarct areas and elevated GGT levels.