Review Article
Risk Factors Associated with Cognitive Decline after Cardiac Surgery: A Systematic Review
Table 2
Studies investigating POCD associated with intraoperative blood pressure variation.
| Study | Study design | Number of patients | Type of intervention | Time of assessment | Outcome |
| Gold et al., 1995 [8] | RCT | 248 | High (80–100 mmHg) versus low (50–60 mmHg) BP | 6 months | Decline with lower BP |
Siepe et al., 2011 [9] | RCT | 92 | High (80–90 mmHg) versus low (60–70 mmHg) BP | 2 days | Decline with lower BP | Gottesman et al., 2007 [51] | Obsv. | 15 | Low MAP (50–70 mmHg) | 3–5 days and 1 month | Decline with lower BP | Newman et al., 1995 [52] | Obsv. | 237 | Low MAP (50–60 mmHg) | Discharge | Decline with lower BP | Charlson et al., 2007 [10] | RCT | 412 | High MAP (57–90 mmHg) versus custom (capped at 90 mmHg) | 6 months | No difference in outcome |
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Obsv.: observational.
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