Table of Contents
Cardiovascular Psychiatry and Neurology
Volume 2016 (2016), Article ID 3915767, 14 pages
http://dx.doi.org/10.1155/2016/3915767
Research Article

Effects of Swimming Exercise on Limbic and Motor Cortex Neurogenesis in the Kainate-Lesion Model of Temporal Lobe Epilepsy

1Department of Anatomy, American University of Antigua College of Medicine, St. John’s, Antigua and Barbuda
2Department of Anatomy, Melaka Manipal Medical College, Manipal University, Manipal 576104, India
3Gandhi Medical College, Hyderabad 500003, India
4Department of Clinical Medicine, American University of Antigua College of Medicine, St. John’s, Antigua and Barbuda
5Department of Medical Physiology, American University of Antigua College of Medicine, St. John’s, Antigua and Barbuda

Received 27 October 2015; Revised 24 April 2016; Accepted 3 May 2016

Academic Editor: Janusz K. Rybakowski

Copyright © 2016 Vasavi R. Gorantla et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Temporal lobe epilepsy (TLE) is a common neurological disease and antiseizure medication is often inadequate for preventing apoptotic cell death. Aerobic swimming exercise (EX) augments neurogenesis in rats when initiated immediately in the postictal period. This study tests the hypothesis that aerobic exercise also augments neurogenesis over the long term. Male Wistar rats (age of 4 months) were subjected to chemical lesioning using KA and to an EX intervention consisting of a 30 d period of daily swimming for 15 min, in one experiment immediately after KA lesioning (immediate exposure) and in a second experiment after a 60 d period of normal activity (delayed exposure). Morphometric counting of neuron numbers (NN) and dendritic branch points and intersections (DDBPI) was performed in the CA1, CA3, and dentate regions of hippocampus, in basolateral nucleus of amygdala, and in several areas of motor cortex. EX increased NN and DDBPI in the normal control and the KA-lesioned rats in all four limbic and motor cortex areas studied, after both immediate and 60 d delayed exposures to exercise. These findings suggest that, after temporal lobe epileptic seizures in rats, swimming exercise may improve neural plasticity in areas of the brain involved with emotional regulation and motor coordination, even if the exercise treatment is delayed.