Cardiovascular Psychiatry and Neurology

Blood-Brain Barrier Breakdown and Blood-Brain Communication in Neurological and Psychiatric Diseases


Publishing date
01 Mar 2011
Status
Published
Submission deadline
01 Nov 2010

Lead Editor
Guest Editors

1Departments of Physiology, Neurosurgery, and Biomedical Engineering, Ben-Gurion University of the Negev, Beersheba 84105, Israel

2Department of Integrative Biology, Helen Wills Neuroscience Institute, University of California at Berkeley, CA 94720-3140, USA


Blood-Brain Barrier Breakdown and Blood-Brain Communication in Neurological and Psychiatric Diseases

Description

Many neurological disorders including brain trauma, ischemia, infections, epilepsy, and neurodegenerative have been reported to be associated with breakdown of the blood-brain barrier (BBB). Recent series of studies suggest a direct role for BBB permeability changes and abnormal blood-brain communication in the pathogenesis and symptomatology associated with specific neurological or psychiatric brain diseases, including epilepsy, stroke, and depression. The mechanisms include effects of blood components on neuronal, asrtocytic and oligodendrocytic functions, as well as abnormal signaling related to inflammation. The cumulative data suggest the BBB and blood-brain communication as potential targets for prevention and treatment of brain disorders.

This special issue focuses on topics relating blood-brain communication to disease generation, development, and prevention. The authors are invited to present original research articles, review articles, or hypotheses papers on BBB damage and repair mechanisms, potential blood-brain communication, and inflammation-related mechanisms. Specifically, papers discussing pathophysiological processes that occur before, during, and following BBB disruption which may contribute to a better understanding of neurological and psychiatric disorders and promote novel diagnostic means and therapeutic targets are requested. Effort should be made to target translational neuroscience and focus on novel therapeutic targets. We also invite authors to present novel ideas and reviews on diagnosis of altered vascular-neuronal signaling. The presentation of the original hypothesis in a review article does not require any new data. The hypothesis should be explicitly stated, the testing of the hypothesis should be detailed including the existing data in support and against the hypothesis (extensive review of the literature should be avoided), and the implications of the hypothesis should be clearly identified. Submission of supporting figures and tables is encouraged.

Before submission authors should carefully read over the journal's Author Guidelines, which are located at http://www.hindawi.com/journals/cpn/guidelines/. Prospective authors should submit an electronic copy of their complete manuscript through the journal Manuscript Tracking System at http://mts.hindawi.com/ according to the following timetable:


Articles

  • Special Issue
  • - Volume 2011
  • - Article ID 431470
  • - Editorial

Blood-Brain Barrier Breakdown and Blood-Brain Communication in Neurological and Psychiatric Diseases

Alon Friedman | Daniela Kaufer
  • Special Issue
  • - Volume 2011
  • - Article ID 175364
  • - Hypothesis

Intercellular Interactomics of Human Brain Endothelial Cells and Th17 Lymphocytes: A Novel Strategy for Identifying Therapeutic Targets of CNS Inflammation

Arsalan S. Haqqani | Danica B. Stanimirovic
  • Special Issue
  • - Volume 2011
  • - Article ID 615829
  • - Hypothesis

The Blood-Brain Barrier and Microvascular Water Exchange in Alzheimer's Disease

Valerie C. Anderson | David P. Lenar | ... | William D. Rooney
  • Special Issue
  • - Volume 2011
  • - Article ID 169580
  • - Research Article

A Novel Algorithm for the Assessment of Blood-Brain Barrier Permeability Suggests That Brain Topical Application of Endothelin-1 Does Not Cause Early Opening of the Barrier in Rats

D. Jorks | D. Milakara | ... | J. P. Dreier
  • Special Issue
  • - Volume 2011
  • - Article ID 482415
  • - Review Article

The Etiological Role of Blood-Brain Barrier Dysfunction in Seizure Disorders

Nicola Marchi | William Tierney | ... | Damir Janigro
  • Special Issue
  • - Volume 2011
  • - Article ID 461263
  • - Review Article

Elucidating the Complex Interactions between Stress and Epileptogenic Pathways

Aaron R. Friedman | Luisa P. Cacheaux | ... | Daniela Kaufer
  • Special Issue
  • - Volume 2011
  • - Article ID 469046
  • - Research Article

Effects of Neonatal Systemic Inflammation on Blood-Brain Barrier Permeability and Behaviour in Juvenile and Adult Rats

H. B. Stolp | P. A. Johansson | ... | C. J. Ek
  • Special Issue
  • - Volume 2011
  • - Article ID 130406
  • - Hypothesis

Occult Cerebrovascular Disease and Late-Onset Epilepsy: Could Loss of Neurovascular Unit Integrity Be a Viable Model?

Lorna M. Gibson | Stuart M. Allan | ... | Hedley C. A. Emsley
  • Special Issue
  • - Volume 2011
  • - Article ID 765923
  • - Research Article

Blood-Brain Barrier Breakdown Following Traumatic Brain Injury: A Possible Role in Posttraumatic Epilepsy

Oren Tomkins | Akiva Feintuch | ... | Ilan Shelef
  • Special Issue
  • - Volume 2011
  • - Article ID 609202
  • - Review Article

Vascular Pathology and Blood-Brain Barrier Disruption in Cognitive and Psychiatric Complications of Type 2 Diabetes Mellitus

Yonatan Serlin | Jaime Levy | Hadar Shalev

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