Development and Validation of New Chromatographic Method for the Determination of Enantiomeric and Diastereomeric Purity of Solifenacin Succinate: An Antimuscarinic Agent

<table>(a) Isomer elution order using n-Hexane : IPA : DEA (70 : 30 : 0.1) mobile phase. (b) Isomer elution order using n-Hexane : EtOH : DEA (85 : 15 : 0.1) mobile phase. (c) Typical chromatogram representing isomeric separation of Solifenacin Succinate using n-Hexane : EtOH : IPA : DEA (60 : 15 : 25 : 0.1) mobile phase. (All trials have been conducted at column temperature <svg height="11.225" id="M26" style="vertical-align:-0.17555pt" version="1.1" viewbox="0 0 20.200001 11.225" width="20.200001" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,11.225)">
<g transform="translate(72,-63.02)">
<text transform="matrix(1,0,0,-1,-71.95,63.24)">
<tspan style="font-size: 12.50px; " x="0" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">5</tspan>
</text>
<text transform="matrix(1,0,0,-1,-59.45,68.56)">
<tspan style="font-size: 8.75px; " x="0" y="0">∘</tspan>
</text>
</g>
</g>
</svg>C).</table>

Chromatography Research International

fig2

Figure 2

Figure 2: Development and Validation of New Chromatographic Method for the Determination of Enantiomeric and Diastereomeric Purity of Solifenacin Succinate: An Antimuscarinic Agent 

Figure 2 | Development and Validation of New Chromatographic Method for the Determination of Enantiomeric and Diastereomeric Purity of Solifenacin Succinate: An Antimuscarinic Agent 