Development and Validation of New Chromatographic Method for the Determination of Enantiomeric and Diastereomeric Purity of Solifenacin Succinate: An Antimuscarinic Agent
Figure 4
Method selectivity as illustrated by a typical chromatogram of solifenacin spiked with its precursor and stereoisomers at 0.15% level. (Chromatographic conditions- Chiralpak-IC, 250 mm 4.6 mm ID column; mobile phase- n-hexane : ethanol : isopropyl alcohol : diethyl amine (60 : 15 : 25 : 0.1, v/v/v/v); flow rate 1.0 mL/min; column temperature C; wavelength 220 nm).