Development and Validation of New Chromatographic Method for the Determination of Enantiomeric and Diastereomeric Purity of Solifenacin Succinate: An Antimuscarinic Agent

<table class="table-group" id="tab1"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td align="left" rowspan="2">Component</td><td align="center" colspan="3">System suitability parameter</td></tr><tr><td align="center">Theoretical plate</td><td align="center">Asymmetry</td><td align="center">Resolution</td></tr><tr><td align="center" colspan="4"><hr/></td></tr><tr><td align="left">Isomer-1</td><td align="center">9320</td><td align="center">1.17</td><td align="center">—</td></tr><tr><td align="left">Isomer-2</td><td align="center">8627</td><td align="center">1.18</td><td align="center">3.2</td></tr><tr><td align="left">Isomer-3</td><td align="center">7900</td><td align="center">1.18</td><td align="center">6.4</td></tr><tr><td align="left">Solifenacin</td><td align="center">7415</td><td align="center">1.15</td><td align="center">5.7</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Chromatographic characteristics of system suitability solution.

Chromatography Research International

tab1

Table 1

Table 1: Development and Validation of New Chromatographic Method for the Determination of Enantiomeric and Diastereomeric Purity of Solifenacin Succinate: An Antimuscarinic Agent 

Table 1 | Development and Validation of New Chromatographic Method for the Determination of Enantiomeric and Diastereomeric Purity of Solifenacin Succinate: An Antimuscarinic Agent 