Stress Degradation Behavior of Paliperidone, an Antipsychotic Drug, and Development of Suitable Stability-Indicating RP-LC Method

<table class="table-group" width="800px"><tr class="fig-image" id="a"><td><img alt="256812.fig.002a" src="https://static.hindawi.com/articles/cri/volume-2011/256812/figures/256812.fig.002a.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(a) </b>Unspiked test sample</td></tr></table></td></tr><tr class="fig-image" id="b"><td><img alt="256812.fig.002b" src="https://static.hindawi.com/articles/cri/volume-2011/256812/figures/256812.fig.002b.jpg"/></td></tr><tr class="fig-caption"><td align="center"><table><tr><td><b>(b) </b>Spiked test sample</td></tr></table></td></tr></table>

<table>Typical RP-HPLC chromatograms of (a) paliperidone unspiked test preparation and (b) paliperidone spiked test preparation with known impurities (Imp-A, Imp-B, Imp-C, Imp-D, and Imp-E).</table>

Chromatography Research International

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Figure 2

Figure 2: Stress Degradation Behavior of Paliperidone, an Antipsychotic Drug, and Development of Suitable Stability-Indicating RP-LC Method 