Table of Contents
Chromatography Research International
Volume 2011, Article ID 632820, 6 pages
http://dx.doi.org/10.4061/2011/632820
Research Article

Development of LC Method for the Simultaneous Determination of Antidepressant Drug Combination Melitracen Hydrochloride and Flupentixol Dihydrochloride in their Combined Dosage Form

1Department of Pharmaceutical Chemistry and Analysis, Indukaka Ipcowala College of Pharmacy, Beyond GIDC, P.B. no. 53, New Vallabh Vidyanagar 388 121, India
2Sophisticated Instrumentation Centre for Applied Research and Testing, Vallabh Vidyanagar 388 120, India

Received 18 December 2010; Revised 29 March 2011; Accepted 4 April 2011

Academic Editor: Irene Panderi

Copyright © 2011 Usmangani K. Chhalotiya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. K. D. Tripathi, Essentials of Medical Pharmacology, Jaypee brothers Medical Publishers, New Delhi, India, 5th edition, 2003.
  2. M. J. O. Neil, Ed., The Merck Index: An Encyclopedia of Chemical, Drug's and Biologicals, Merck Research Lab, Division of Merck and co. Inc., Whitehouse Station, NJ, USA, 14th edition, p. 1006, 2006.
  3. M. J. O. Neil, Ed., The Merck Index: An Encyclopedia of Chemical, Drug's and Biologicals, Merck Research Lab, Division of Merck and co. Inc., Whitehouse Station, NJ, USA, 14th edition, p. 14,716, 2006.
  4. British Pharmacopoeia, Vol. I, The Stationary Office, London, UK, 2002.
  5. H. Bin Yaacob, “Flupenthixol and Melitracen in the management of trigeminal neuralgia,” Dental journal of Malaysia, vol. 8, no. 2, pp. 37–38, 1985. View at Google Scholar · View at Scopus
  6. M. C. Sharma, S. Sharma, and A. D. Sharma, “Novel application and spectrophotometric estimation of Melitracen HCl tablet dosage form using niacinamide as hydrotropic solubilizing agent,” Journal of Chemical and Pharmaceutical Research, vol. 2, no. 2, pp. 416–420, 2010. View at Google Scholar
  7. I. A. Sheikh, M. Charde, and A. V. Kasture, “Development of spectrophotometric method for simultaneous estimation of flupentixolHCl and melitracen HCl in their combined dosage form,” Asian Journal of Research in Chemistry, vol. 2, no. 4, pp. 488–493, 2009. View at Google Scholar
  8. P. Xu, H. D. Li, Y. G. Zhu et al., “Validated liquid-liquid extraction and LC-ESI-MS method for the determination of melitracen in human plasma,” Chromatographia, vol. 67, pp. 11–12, 2008. View at Publisher · View at Google Scholar · View at Scopus
  9. E. Tanaka, M. Terada, T. Nakamura, S. Misawa, and C. Wakasugi, “Forensic analysis of eleven cyclic antidepressants in human biological samples using a new reversed-phase chromatographic column of 2 μm porous microspherical silica gel,” Journal of Chromatography B, vol. 692, no. 2, pp. 405–412, 1997. View at Publisher · View at Google Scholar · View at Scopus
  10. M. Kollroser and C. Schober, “Simultaneous determination of seven tricyclic antidepressant drugs in human plasma by direct-injection HPLC-APCI-MS-MS with an ion trap detector,” Therapeutic Drug Monitoring, vol. 24, no. 4, pp. 537–544, 2002. View at Publisher · View at Google Scholar · View at Scopus
  11. T. Shinozuka, M. Terada, and E. Tanaka, “Solid-phase extraction and analysis of 20 antidepressant drugs in human plasma by LC/MS with SSI method,” Forensic Science International, vol. 162, no. 1–3, pp. 108–112, 2006. View at Publisher · View at Google Scholar · View at Scopus
  12. X. C. Zuo, BI. K. Zhang, B. M. Chen et al., “LC-ESI-MS determination of flupentixol in human plasma,” Chromatographia, vol. 69, no. 3-4, pp. 301–305, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. W. Weinmann, C. Müller, S. Vogt, and A. Frei, “LC-MS-MS analysis of the neuroleptics clozapine, flupentixol, haloperidol, penfluridol, thioridazine, and zuclopenthixol in hair obtained from psychiatric patients,” Journal of Analytical Toxicology, vol. 26, no. 5, pp. 303–307, 2002. View at Google Scholar · View at Scopus
  14. L. G. Garcia, I. Forfar-Bares, F. Pehourcq, and C. Jarry, “Simultaneous determination of four antipsychotic drugs in plasma by high-performance liquid chromatography: application to management of acute intoxications,” Journal of Chromatography B, vol. 795, no. 2, pp. 257–264, 2003. View at Publisher · View at Google Scholar · View at Scopus
  15. S. Ulrich, “Sensitive gas-liquid chromatographic method for the assay of the neuroleptic drug cis(Z)-flupentixol in human serum or plasma,” Journal of Chromatography B, vol. 668, no. 1, pp. 31–40, 1995. View at Publisher · View at Google Scholar · View at Scopus
  16. H. Kirchherr and W. N. Kühn-Velten, “Quantitative determination of forty-eight antidepressants and antipsychotics in human serum by HPLC tandem mass spectrometry: a multi-level, single-sample approach,” Journal of Chromatography B, vol. 843, no. 1, pp. 100–113, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. S. Walter, S. Bauer, I. Roots, and J. Brockmöller, “Quantification of the antipsychotics flupentixol and haloperidol in human serum by high-performance liquid chromatography with ultraviolet detection,” Journal of Chromatography B, vol. 720, no. 1-2, pp. 231–237, 1998. View at Publisher · View at Google Scholar · View at Scopus
  18. J. Che, Q. Meng, Z. Chen, C. San, Y. Hou, and Y. Cheng, “Validation of a sensitive LC/MS/MS method for simultaneous quantitation of flupentixol and melitracen in human plasma,” Journal of Pharmaceutical and Biomedical Analysis, vol. 45, no. 5, pp. 785–792, 2007. View at Publisher · View at Google Scholar · View at Scopus