Development of LC Method for the Simultaneous Determination of Antidepressant Drug Combination Melitracen Hydrochloride and Flupentixol Dihydrochloride in their Combined Dosage Form

Table 4

Data derived from robustness for proposed method.

Parameters	Normal condition	Change in condition	Change in % RSD
			MEL	FLU
Flow Rate	1.0 mL/min	0.9  mL/min	0.33	0.21
		1.1  mL/min	0.48	0.11
pH	7.3	6.8	0.28	0.13
		7.8	0.31	0.18
Mobile phase ratio	90 : 10	95 : 5	0.17	0.13
		85 : 15	0.23	0.18