Research Article
Development and Validation of HPTLC Method for Estimation of Carbamazepine in Formulations and Its In Vitro Release Study
Table 6
Solubility of Carbamazepine in various excipients and buffers.
| | Excipients | Solubilitya |
| | Oily phases | | | Labrafil M 1944 (Oleoyl polyoxylglycerides) | 37.7 4.21 | | Labrafac CC (Caprylic/Capric Triglycerides) | 10.47 3.6 | | Isopropyl Myristate | 21.9 3.9 | | Labrafac Lipophile (Medium chain triglycerides) | 0.9 0.7 | | Labrafac PG (Propylene glycol dicaprylocaprate) | 1.1 0.7 | | Miglyol 810 (Caprylic/Capric Triglyceride) | 1.31 1.0 | | Miglyol 812 (Caprylic/Capric Triglyceride) | 1.6 0.9 | | Miglyol 840 (Propylene Glycol Dicaprylate/Dicaprate) | 0.7 0.36 | | Lauryl Alcohol | 1.8 0.6 | | Isostearylic isostearate | 1.44 0.6 | | Isopropyl Palmitate | 0.35 0.21 | | Captex 200 (Propylene Glycol Dicaprylate/Dicaprate) | 3.8 0.9 | | Captex 355 (Glycerol Caprylate Caprate) | 1.8 0.7 |
| | Surfactants | | | Labrasol (Caprylocaproyl Polyoxylglycerides) | 165.8 6.16 | | Tween (Polysorbate) 80 | 75.0 6.18 | | Plurol Stearique WL (Polyglyceryl-6-distearate) | 0.8 0.15 | | Plurol Diisostearique (Polyglyceryl diisostearate) | 1.05 0.7 | | Cremophor RH 40 (Polyoxyl 40 Hydrogenated Castor Oil) | 25.34 6.11 |
| | Cosurfactants | | | Plurol Oleique CC (Polyglyceryl oleate) | 4.13 1.1 | | Plurol Oleique 5203 (Polyglyceryl 6-dioleate) | 1.7 0.8 | | Lauroglycol 90 (Propylene glycol monolaurate) | 49.8 3.1 | | Capryol 90 (Propylene glycol monocaprylate) | 87.44 5.8 | | Transcutol P (Diethylene glycol monoethyl ether) | 157.23 7.34 | | Capmul MCM (Glyceryl Mono- & dicaprate) | 11.14 4.1 | | Propylene glycol | 150.9 4.6 |
| | Aqueous Phases
b | | | Phosphate buffer pH 5.0 | 51.32 2.9 | | Phosphate buffer pH 6.0 | 65.5 3.42 | | Phosphate buffer pH 6.5 | 45.9 2.28 |
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aData expressed as mg/g, mean SD, .
bData expressed as μg/mL, mean SD, .
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