Determination of Glucosamine in Human Plasma by High-Performance Liquid Chromatography-Atmospheric Pressure Chemical Ionization Source-Tandem Mass Spectrometry

<table class="table-group" id="tab5"><tr><td><table class="table"><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr class="thead"><td align="left">Parameters</td><td align="center">Test tablet</td><td align="center">Reference tablet</td></tr><tr><td class="thead-hr" colspan="3"><hr/></td></tr><tr><td align="left"><svg height="13.05" id="M56" style="vertical-align:-3.25793pt" version="1.1" viewbox="0 0 19.625 13.05" width="19.625" xmlns="http://www.w3.org/2000/svg">
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<g transform="translate(72,-62.26)">
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</svg>/<i>μ</i>g·L<sup>−1</sup></td><td align="center"><span style="width: 72.474998px;"><svg height="12.2375" id="M63" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 72.474998 12.2375" width="72.474998" xmlns="http://www.w3.org/2000/svg">
<g transform="matrix(1.25,0,0,-1.25,0,12.2375)">
<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">8</tspan>
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<tspan style="font-size: 12.50px; " x="45.373386" y="0">6</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">8</tspan>
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<g transform="translate(72,-62.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.4)">
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<tspan style="font-size: 12.50px; " x="18.754499" y="0">6</tspan>
<tspan style="font-size: 12.50px; " x="27.781666" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="39.121887" y="0">6</tspan>
<tspan style="font-size: 12.50px; " x="45.373386" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">8</tspan>
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</svg></span></td></tr><tr><td align="left">AUC<sub>0→24</sub>/<i>μ</i>g·h·L<sup>−1</sup></td><td align="center"><span style="width: 80.287498px;"><svg height="12.2375" id="M65" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 80.287498 12.2375" width="80.287498" xmlns="http://www.w3.org/2000/svg">
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<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">6</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">0</tspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">3</tspan>
<tspan style="font-size: 12.50px; " x="18.754499" y="0">3</tspan>
<tspan style="font-size: 12.50px; " x="27.781666" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="39.121887" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="45.373386" y="0">5</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">6</tspan>
<tspan style="font-size: 12.50px; " x="57.876389" y="0">0</tspan>
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</svg></span></td><td align="center"><span style="width: 80.287498px;"><svg height="12.2375" id="M66" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 80.287498 12.2375" width="80.287498" xmlns="http://www.w3.org/2000/svg">
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<g transform="translate(72,-62.21)">
<text transform="matrix(1,0,0,-1,-71.95,63.35)">
<tspan style="font-size: 12.50px; " x="0" y="0">5</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">9</tspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">0</tspan>
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<tspan style="font-size: 12.50px; " x="57.876389" y="0">3</tspan>
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<tspan style="font-size: 12.50px; " x="0" y="0">6</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">3</tspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">6</tspan>
<tspan style="font-size: 12.50px; " x="18.754499" y="0">5</tspan>
<tspan style="font-size: 12.50px; " x="27.781666" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="39.121887" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="45.373386" y="0">6</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="57.876389" y="0">2</tspan>
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</g>
</g>
</svg></span></td><td align="center"><span style="width: 80.287498px;"><svg height="12.175" id="M68" style="vertical-align:-1.09097pt" version="1.1" viewbox="0 0 80.287498 12.175" width="80.287498" xmlns="http://www.w3.org/2000/svg">
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<g transform="translate(72,-62.26)">
<text transform="matrix(1,0,0,-1,-71.95,63.4)">
<tspan style="font-size: 12.50px; " x="0" y="0">6</tspan>
<tspan style="font-size: 12.50px; " x="6.2515001" y="0">2</tspan>
<tspan style="font-size: 12.50px; " x="12.503" y="0">8</tspan>
<tspan style="font-size: 12.50px; " x="18.754499" y="0">4</tspan>
<tspan style="font-size: 12.50px; " x="27.781666" y="0">±</tspan>
<tspan style="font-size: 12.50px; " x="39.121887" y="0">1</tspan>
<tspan style="font-size: 12.50px; " x="45.373386" y="0">4</tspan>
<tspan style="font-size: 12.50px; " x="51.624886" y="0">7</tspan>
<tspan style="font-size: 12.50px; " x="57.876389" y="0">8</tspan>
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The main pharmacokinetics parameters of glucosamine in 20 healthy volunteers after an oral administration of 1.44 g of glucosamine hydrochloride.

Chromatography Research International

tab5

Table 5

Table 5: Determination of Glucosamine in Human Plasma by High-Performance Liquid Chromatography-Atmospheric Pressure Chemical Ionization Source-Tandem Mass Spectrometry 

Table 5 | Determination of Glucosamine in Human Plasma by High-Performance Liquid Chromatography-Atmospheric Pressure Chemical Ionization Source-Tandem Mass Spectrometry 