Development and Validation of Stability-Indicating GC-FID Method for the Quantitation of Memantine Hydrochloride and Its Nonchromophoric Impurities in Bulk and Pharmaceutical Dosages

Table 1

System suitability test results.

Compound	Retention time (min)	RRT	Theoretical plate	USP tailing factor (T)	Resolution (𝑅𝑠)
Imp-A	8.04	0.74	212697	0.99	—
Memantine	10.93	1.00	410875	1.40	41.92
Imp-B	13.40	1.23	728847	1.04	37.66
Imp-C	17.36	1.59	1354612	1.00	64.75

RRT: relative retention time.