A Stability Indicating UPLC Method for the Determination of Tramadol Hydrochloride: Application to Pharmaceutical Analysis

Table 6

Results of determination of TMH in tablet and statistical comparison with the reference method.

Formulation brand name	Nominal amount, mg	% TMH found* ± SD		t-value	F-value
		Reference method	Proposed method
Nobligan^a	50.0	101.6 ± 1.64	100.1 ± 0.65	1.94	6.36
Meridol^b	50.0	101.8 ± 1.36	99.98 ± 0.86	2.52	2.50

^aMarketed by Piramal HC Ltd, Mumbai, India.
^bUnimarc India Ltd, Mumbai, India.
*Mean value of five determinations. Tabulated t-value at 95% confidence level is 2.78; Tabulated F-value at 95% confidence level is 6.39.