A Stability Indicating UPLC Method for the Determination of Levofloxacin Hemihydrate in Pharmaceutical Dosage Form: Application to Pharmaceutical Analysis

<table class="table-group" id="tab4"><tr><td><table class="table"><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr class="thead"><td align="left">Stress condition</td><td align="center">Time</td><td align="center">Purity angle</td><td align="center">Purity threshold</td><td align="center">% Degradation</td></tr><tr><td class="thead-hr" colspan="5"><hr/></td></tr><tr><td align="left">Acid Hydrolysis</td><td align="center">1 hr</td><td align="center">0.409</td><td align="center">0.874</td><td align="center">8.12</td></tr><tr><td align="left">Base Hydrolysis</td><td align="center">1 hr</td><td align="center">1.107</td><td align="center">13.28</td><td align="center">12.38</td></tr><tr><td align="left">Oxidation</td><td align="center">1 hr</td><td align="center">4.578</td><td align="center">12.82</td><td align="center">66.44</td></tr><tr><td align="left">Thermal</td><td align="center">1 hr</td><td align="center">0.854</td><td align="center">1.057</td><td align="center">24.37</td></tr><tr><td align="left">Photo</td><td align="center">5 days</td><td align="center">0.748</td><td align="center">1.682</td><td align="center">27.82</td></tr><tr class="table-tr"><td colspan="5"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Chromatography Research International

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Table 4

Table 4: A Stability Indicating UPLC Method for the Determination of Levofloxacin Hemihydrate in Pharmaceutical Dosage Form: Application to Pharmaceutical Analysis 

Table 4 | A Stability Indicating UPLC Method for the Determination of Levofloxacin Hemihydrate in Pharmaceutical Dosage Form: Application to Pharmaceutical Analysis 