Chromatography Research International / 2014 / Article / Tab 3

Research Article

Stability Indicating Liquid Chromatographic Method for Estimation of Trihexyphenidyl Hydrochloride and Risperidone in Tablet Formulation: Development and Validation Consideration

Table 3

Degradation of THP and RSP at different stress conditions.

Stress condition/strength/durationDrugsPeak area% Assay of drug after degradation% Degradation

Acidic/2 N HCl/45 minRSP6853979.09%20.90%
THP2085282.46%17.53%
Basic/1 N NaOH/60 minRSP7567787.29%12.70%
THP2071089.79%18.09%
Oxidative/6% H2O2/2 hrRSP7482086.33%13.66%
THP1990175.53%24.46%
Thermal/dry heating/80°C/60 minRSP8668999.99%No degradation
THP2528699.99%No degradation
Photolytic/UV light/60 min RSP7638591.60%11.88%
THP2252895.02%10.90%

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