Development and Validation of Stability-Indicating RP-UPLC Method for Simultaneous Determination of Related Substances of S(−)Amlodipine and S(−)Metoprolol Succinate in Fixed Dose Combination Tablet Dosage Form

Table 10

Results of method precision and intermediate precision.

Analyst	Metoprolol Succinamide impurity	Amlodipine related compound-A	% of any individual impurity	% of total impurities
I	0.539	0.926	0.050	1.562
	0.539	0.926	0.049	1.562
	0.541	0.926	0.049	1.562
	0.542	0.927	0.051	1.570
	0.539	0.927	0.048	1.561
	0.541	0.931	0.050	1.570
II	0.527	0.861	0.050	1.531
	0.522	0.861	0.052	1.529
	0.522	0.862	0.052	1.530
	0.526	0.862	0.051	1.581
	0.530	0.866	0.050	1.536
	0.529	0.863	0.052	1.576
Mean	0.533	0.895	0.050	1.556
SD	0.008	0.034	0.001	0.019
%RSD	1.50	3.80	2.00	1.22