Development and Validation of Stability-Indicating RP-UPLC Method for Simultaneous Determination of Related Substances of S(−)Amlodipine and S(−)Metoprolol Succinate in Fixed Dose Combination Tablet Dosage Form
Table 12
Results of filter validation.
Sample number
Metoprolol Succinamide impurity
Amlodipine related compound-A
Any individual impurity
Total Impurities
Unfiltered sample preparation
0.560
1.132
0.049
1.789
Filtered sample preparation-1
0.560
1.132
0.048
1.788
Filtered sample preparation-2
0.560
1.132
0.050
1.790
Filtered sample preparation-3
0.560
1.137
0.050
1.795
Filtered sample preparation-4
0.561
1.137
0.048
1.793
Filtered sample preparation-5
0.561
1.138
0.050
1.796
Absolute difference between unfiltered and filtered sample preparation
