Development and Validation of Stability-Indicating RP-UPLC Method for Simultaneous Determination of Related Substances of S(−)Amlodipine and S(−)Metoprolol Succinate in Fixed Dose Combination Tablet Dosage Form

<table class="table-group" id="tab3"><tr><td><table class="table"><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr class="thead"><td align="left">Peak name</td><td align="center">Tailing factor</td><td align="center">Theoretical plates</td><td align="center">%RSD of six injections</td></tr><tr><td class="thead-hr" colspan="4"><hr/></td></tr><tr><td align="left">S(−)Metoprolol</td><td align="center">1.38</td><td align="center">29070</td><td align="center">0.09</td></tr><tr><td align="left">S(−)Amlodipine</td><td align="center">1.06</td><td align="center">144639</td><td align="center">0.73</td></tr><tr class="table-tr"><td colspan="4"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Chromatography Research International

tab3

Table 3

Table 3: Development and Validation of Stability-Indicating RP-UPLC Method for Simultaneous Determination of Related Substances of S(−)Amlodipine and S(−)Metoprolol Succinate in Fixed Dose Combination Tablet Dosage Form 

Table 3 | Development and Validation of Stability-Indicating RP-UPLC Method for Simultaneous Determination of Related Substances of S(−)Amlodipine and S(−)Metoprolol Succinate in Fixed Dose Combination Tablet Dosage Form 