Development and Validation of Stability-Indicating RP-UPLC Method for Simultaneous Determination of Related Substances of S(−)Amlodipine and S(−)Metoprolol Succinate in Fixed Dose Combination Tablet Dosage Form

<table class="table-group" id="tab7"><tr><td><table class="table"><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr class="thead"><td align="left">Analyte</td><td align="center">Correlation coefficient</td></tr><tr><td class="thead-hr" colspan="2"><hr/></td></tr><tr><td align="left">S(−)Metoprolol</td><td align="center">0.99963</td></tr><tr><td align="left">S(−)Amlodipine</td><td align="center">0.99950</td></tr><tr><td align="left">Metoprolol Succinamide impurity</td><td align="center">0.99967</td></tr><tr><td align="left">Amlodipine related compound-A</td><td align="center">0.99959</td></tr><tr class="table-tr"><td colspan="2"><hr class="tbody-hr"/></td></tr></table></td></tr></table>

Results of linearity (correlation coefficient).

Chromatography Research International

tab7

Table 7

Table 7: Development and Validation of Stability-Indicating RP-UPLC Method for Simultaneous Determination of Related Substances of S(−)Amlodipine and S(−)Metoprolol Succinate in Fixed Dose Combination Tablet Dosage Form 

Table 7 | Development and Validation of Stability-Indicating RP-UPLC Method for Simultaneous Determination of Related Substances of S(−)Amlodipine and S(−)Metoprolol Succinate in Fixed Dose Combination Tablet Dosage Form 