Development and Validation of New RP-HPLC Method for Simultaneous Determination of Methyl and Propyl Parabens with Levetiracetam in Pure Form and Pharmaceutical Formulation

Table 2

Accuracy of the proposed HPLC method for determination of LTC, MHB, and PHB in Levepsy syrup.

Levetiracetam			Methyl paraben			Propyl paraben
Nominal conc.	Found conc.	Recovery%	Nominal conc.	Found conc.	Recovery%	Nominal conc.	Found conc.	Recovery%
mgmL^−1	mgmL^−1		µgmL^−1	µgmL^−1		µgmL^−1	µgmL^−1
0.75	0.748	99.72	15	15.199	101.33	1.5	1.4921	99.48
1	0.995	99.51	20	20.134	100.67	2	2.0238	101.19
1.25	1.259	100.73	25	25.261	101.04	2.5	2.5122	100.49
1.5	1.495	99.69	30	29.931	99.77	3	2.9698	98.99
Mean		99.91			100.70			100.04
SD		0.56			0.68			0.99
RSD		0.557			0.672			0.989

Data are average of three experiments.