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Case Reports in Pathology
Volume 2011 (2011), Article ID 564260, 4 pages
http://dx.doi.org/10.1155/2011/564260
Case Report

Tuberous Sclerosis Complex Associated with Papillary Serous Carcinoma of the Peritoneum, Lymphangioleiomyomatosis, and Angiomyolipoma

1Department of Pathology and Microbiology, Faculty of Medicine, Saga University, Saga City 849-8501, Japan
2Department of Neurosurgery, Faculty of Medicine, Saga University, Saga City 849-8501, Japan
3Department of Pathology, School of Medicine, Kurume University, Japan
4Department of Obstetrics and Gynecology, Faculty of Medicine, Saga University, Saga City 849-8501, Japan

Received 4 July 2011; Accepted 16 August 2011

Academic Editors: G. Adonakis and O. Hes

Copyright © 2011 Tomihiro Wakamiya et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Tuberous sclerosis complex (TSC) is associated with benign and malignant tumors, including lymphangioleiomyomatosis (LAM) and angiomyolipoma (AML). We herein describe the TSC case of a 50-year-old woman having a papillary serous carcinoma of the peritoneum (PSCP), LAM, and AML. On microscopic examination, the PSCP cells showed a cuboidal to columnar shape, proliferated into the papillae, and infiltrated into the peritoneal cavity and anterior thoracic wall. On immunohistochemical evaluation, the tumor cells were positive for epithelial membrane antigen, human epidermal cytokeratins, and progesterone receptor, but negative for calretinin, carcinoembryonic antigen, MCF-7 cell line (Ber-EP4), and estrogen receptor.