Amyloid β-Related Angiitis Causing Coma Responsive to Immunosuppression
Figure 1
Amyloid-beta-related angiitis. (a) Magnetic resonance T2 FLAIR imaging at admission to Neuro ICU note hyperintense lesion in the grey and white matter in the right sensorimotor cortex. (b) Hematoxylin-eosin-stained section shows characteristic double barrel lumen appearance of an amyloid laden vessel. (c) Immunohistochemistry using monoclonal antibody against beta-amyloid reacting to vessels in the meninges and parenchyma. (d) Squash prep at time of surgery-blood vessel and extensive perivascular lymphocytic infiltrate. (e) Lymphocytic response with intramural vascular inflammation. (f) Antibody against CD3 demonstrates a perivascular T-cell infiltrate.
