(a) Ultrasound color Doppler highlighting the submucosal lesion with increased vascularity in the second part of the duodenum. (b) Circumscribed lesion in submucosa, with tumor arranged in nesting pattern (H&E 100x). (c) Tumor cells showing abundant cytoplasm and mildly pleomorphic nuclei-ganglion cell morphology (H&E 400x). (d) Spindle cell morphology of tumor cells (H&E 40x). (e) Tumor cells showing synaptophysin positivity. (f) Tumor cells showing strong reaction with S-100 immunohistochemical stain.