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Case Reports in Pathology
Volume 2013, Article ID 459279, 4 pages
Case Report

Pleural Fluid Cytology of the Polymorphous Variant of EBV-Positive Diffuse Large B-Cell Lymphoma: First Report and Distinction from a Reactive Process

1Department of Pathology, Johns Hopkins University, Baltimore, MD 21287, USA
2Johns Hopkins Bayview Medical Center, Pathology 1 Floor, Room AA158, 4940 Eastern Avenue, Baltimore, MD 21224, USA

Received 21 June 2013; Accepted 2 August 2013

Academic Editors: Y. L. Choi and V. Reddy

Copyright © 2013 Lisa Rooper et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


EBV-positive diffuse large B-cell lymphoma of the elderly is a newly described aggressive lymphoma predominantly affecting patients >50 years of age. Patients may present with nodal and/or extranodal involvement. The lung is one of the more common extranodal sites. The incidence of pleural fluid involvement is less well described. In one study by Oyama et al., pleural effusions were noted in nine percent of cases. Identification of pleural fluid involvement could be important as it may carry prognostic importance in staging (it typically occurs more often in cases with widespread disease), and it could be a relatively easy means of establishing a diagnosis in newly presenting cases. We report the first description of the pleural fluid cytology in a case of EBV-positive diffuse large B-cell lymphoma of the elderly.