Acinic Cell Carcinoma of the Breast Arising in Microglandular Adenosis
Figure 1
Craniocaudal (a) and oblique (b) view of mammography imaging showing radiopacity and thickening with microcalcifications (arrow). (c) Echographic study of the lesion showing, in the same area of (a) and (b), some nodular features. (d) Gross feature of the surgical specimen showing irregular whitish nodule of about 3 cm of diameter with a 8 mm small pseudocystic area. (e) Panoramic view showing nodular and pseudocystic arrangement of tumor (H/E, 100x). (f) Microglandular and microacinar features of tumour cells with small glandular structures arranged back to back and interspersed within fat or fibrous septa (H/E, 100x). (g) High power view of the solid features of the lesion showing high pleomorphic cells, mitotic activity, and necrosis (H/E, 400x). (h) High power view of microglandular structures showing colloid-like secretion in the central lumina and cytoplasmic eosinophilic granules (H/E, 400x). (i) High power view showing colloid-like secretion and cytoplasmic eosinophilic granules after PAS-diastase reaction (H/E, 400x).
