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Case Reports in Pathology
Volume 2014, Article ID 193802, 4 pages
Case Report

Concurrent Liver Hodgkin Lymphoma and Nodular Regenerative Hyperplasia on an Explanted Liver with Clinical Diagnosis of Alcoholic Cirrhosis at University Hospital Fundación Santa Fe de Bogotá

1Pathology and Clinical Laboratory Department, University Hospital Fundación Santa Fe de Bogotá, Calle 119 No. 7–75, Bogotá 110111, Colombia
2Transplant Service, University Hospital Fundación Santa Fe de Bogotá, Calle 119 No. 7–75, Bogotá 110111, Colombia
3School of Medicine, Universidad de los Andes, Cra 1 No. 18A-12, Bogotá 111711, Colombia

Received 15 November 2013; Accepted 11 December 2013; Published 5 January 2014

Academic Editors: M. Guindi and H. Kuwabara

Copyright © 2014 R. López et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Liver involvement by Hodgkin lymphoma (HL) is well documented. However, secondary liver failure to this neoplastic process is rare and usually presents late in the course of the disease. We present a case of a HL associated with nodular regenerative hyperplasia (NRH) diagnosed on an explanted liver from a 53-year-old patient with clinical diagnosis of alcoholic cirrhosis. Hematoxylin and eosin stain (H&E) showed abnormal liver architecture with hepatocytes nodules highlighted by reticulin stain with absent fibrosis on the trichrome stain. The portal spaces had diffuse infiltration by Reed-Sternberg cells positive for CD15, CD30, and latent membrane protein (LMP) on immunohistochemical studies. The patient also had a concurrent hilar lymph node biopsy that also showed HL involvement. Liver failure as the initial presentation of Hodgkin’ lymphoma is rare. We believe that more research about the utility of performing liver biopsies in patients candidates for transplantation with noncirrhotic hepatic failure is needed in order to establish the etiology and the optimal treatment.