Case Report
HER2-Positive Metaplastic Spindle Cell Carcinoma Associated with Synchronous Bilateral Apocrine Carcinoma of the Breast
Table 1
Immunohistochemical results for each tumor morphology.
| Immunohistochemistry
| Left
apocrine
| Right
apocrine | Spindle |
| | ER | − | − | − | | PgR | − | − | − | | AR | + | + | − | | GCDFP-15 | + | + | − | | HER2 | + | + | + | | Cytokeratin CAM5.2 | + | + | Focal | | Cytokeratin AE1/AE3 | + | + | − | | Cytokeratin 34E12 | Focal | Focal | − | | Cytokeratin 5/6 | − | − | − | | Vimentin | − | − | + | | CD10 | − | − | + | | -Smooth muscle actin | − | − | Focal | | h-Caldesmon | − | − | − | | Bcl-2 | − | − | − | | CD34 | − | − | − | | p63 | − | − | − | | MIB-1 index | 13.0% | 10.5% | 37.3% |
|
|
+: positive; −: negative.
|
