An Unusual Case of Systemic Inflammatory Myofibroblastic Tumor with Successful Treatment with ALK-Inhibitor
Figure 2
Histologic appearance of IMT lesions in liver and lumbar spine. (a) and (b) Liver tissue with marked inflammatory cells and spindle cell proliferation expanding portal areas and extending into parenchyma. Adjacent normal liver is seen on upper left corner of (a), (H&E), 5x (a) and 20x (b). (c) Spindle cells show strong and diffuse immunoreactivity to SMA, 20x. (d) Spindle cells are immunoreactive for cytoplasmic anaplastic lymphoma kinase protein (ALK-1), 20x. (e) and (f) Lumbar spine is infiltrated by similar mixture of inflammatory and spindled cells expanding the bone marrow, H&E, 5x and 20x.
