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Case Reports in Pathology
Volume 2014, Article ID 615426, 4 pages
Case Report

Granulomatous Pancreatitis in a Patient with Acute Manifested Insulin-Dependent Diabetes Mellitus

1Department of Pathology, Third Faculty of Medicine, Charles University in Prague, 100 00 Prague 10, Czech Republic
2Department of Pathology, Regional Hospital Jihlava, 586 33 Jihlava, Czech Republic
3Second Department of Internal Medicine, Third Faculty of Medicine, Charles University in Prague, 100 00 Prague, Czech Republic

Received 6 January 2014; Accepted 27 January 2014; Published 5 March 2014

Academic Editors: D. Jain, J. S. Khurana, M. M. Picken, and T. Strecker

Copyright © 2014 Václav Mandys et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Isolated granulomatous noncaseating pancreatitis is a rare condition exceptionally described in human population. We demonstrate a case of the a 71-years-old female patient suffering from recent diabetes mellitus, generalized atherosclerosis and hypertension who died due to pulmonary embolism and terminal bronchopneumonia. Lipomatosis of pancreatic tissue was observed during the postmortem examination. Histological examination of pancreatic tissue discovered multiple small noncaseating epithelioid cell and giant cell granulomas, partly replacing the islets of Langerhans. To our knowledge, our case represents the first description of noninfectious granulomatous pancreatitis associated with acute manifested insulin-dependent diabetes mellitus.