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Case Reports in Pathology
Volume 2014 (2014), Article ID 871530, 4 pages
Case Report

Cellular Angiofibroma of the Prostate: A Rare Tumor in an Unusual Location

1Department of Pathology, KU Leuven and University Hospitals Leuven, UZ Gasthuisberg, Herestraat 49, 3000 Leuven, Belgium
2Human Genetics, KU Leuven and University Hospitals Leuven, 3000 Leuven, Belgium
3Urology, KU Leuven and University Hospitals Leuven, 3000 Leuven, Belgium

Received 8 April 2014; Revised 17 June 2014; Accepted 18 June 2014; Published 1 July 2014

Academic Editor: Dengfeng Cao

Copyright © 2014 Inez Wyn et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We report the unusual occurrence of a cellular angiofibroma in prostatic tissue. In this case, a 84-year-old man presented in the emergency room with urinary retention. Ultrasound revealed an enlarged prostate, which was suggestive for benign prostatic hyperplasia. The patient was treated with a Millin retropubic prostatectomy. Macroscopically the prostate contained multiple circumscribed nodules. Microscopic examination of the tumor showed the appearance of cellular angiofibroma, consisting of bland spindle cells and prominent, hyalinized vessels. The diagnosis was supported by FISH, which revealed monoallelic loss of RB1/13q14 region, as seen in spindle cell lipoma, (extra-) mammary myofibroblastoma, and cellular angiofibroma. Cellular angiofibromas are rare, benign soft tissue tumours and were never reported in the prostatic gland.