Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Pathology
Volume 2014, Article ID 979137, 3 pages
Case Report

Pleomorphic Invasive Ductal Carcinoma of the Breast in a Patient with Huntington’s Disease

Department of Histopathology, Imperial College Healthcare NHS Trust and Imperial College, Charing Cross Hospital, Fulham Palace Road, London W6 8RF, UK

Received 22 August 2014; Revised 18 November 2014; Accepted 25 November 2014; Published 9 December 2014

Academic Editor: Piero Tosi

Copyright © 2014 Sami Shousha. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A pleomorphic invasive ductal carcinoma developed in a patient with Huntington’s disease. The tumour showed marked nuclear pleomorphism and contained large number of bizarre tumour giant cells and abundant abnormal mitoses. Tumour cells showed nuclear vesicles and inclusions similar to those described in nuclei of neural cells in patients with Huntington’s disease. The case suggests that, in some patients, tumour morphology may reflect specific individual features.