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Case Reports in Pathology
Volume 2015, Article ID 231070, 4 pages
Case Report

High Grade (Large Cell) Neuroendocrine Carcinoma of the Nasopharynx: Novel Case Report with Touch Preparation Cytology and Positive EBV Encoded Early RNA

1Cleveland Clinic, Tomsich Pathology Institute, 9500 Euclid Avenue L25, Cleveland, OH 44195, USA
2Cleveland Clinic, Head and Neck Institute, 9500 Euclid Avenue A71, Cleveland, OH 44195, USA

Received 24 December 2014; Accepted 26 April 2015

Academic Editor: Paolo Perrini

Copyright © 2015 Charles D. Sturgis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Fewer than five case reports of primary large cell neuroendocrine carcinoma of the nasopharynx are known to the authors. No previous reports have included examples of cytomorphology or have proven association with Epstein-Barr virus. We herein illustrate MRI findings, histopathologic features, immunohistochemical characterization, cytologic details, and in situ hybridization studies from a unique case of primary large cell neuroendocrine carcinoma of the nasopharynx in a 38-year-old Caucasian male patient. Recognition of rare tumor types of the nasopharynx allows for refinements in disease management and prognostication.