Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Pathology
Volume 2015 (2015), Article ID 245026, 5 pages
http://dx.doi.org/10.1155/2015/245026
Case Report

Ameloblastic Fibrosarcoma of the Mandible: A Case Report and Brief Review of the Literature

1Pathology Department, University Hospital “Dr. Jose E. Gonzalez” and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, Mexico
2Otolaryngology-Head and Neck Surgery Department, University Hospital “Dr. Jose E. Gonzalez” and Medical School of the Autonomous University of Nuevo Leon, Francisco I. Madero and Gonzalitos, 64460 Monterrey, NL, Mexico

Received 11 January 2015; Accepted 2 March 2015

Academic Editor: Khin Thway

Copyright © 2015 Abelardo Loya-Solis et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Ameloblastic fibrosarcoma is an uncommon odontogenic tumor composed of a benign epithelial component and a malignant ectomesenchymal component most frequently seen in the third and fourth decades of life. It mainly presents as a painful maxillary or mandibular swelling. Radiographs show a radiolucent mass with ill-defined borders. Radical surgical excision and long-term follow-up are the suggested treatment. We report the case of a 22-year-old female with a 2-month history of an asymptomatic swelling in her left mandible. Examination revealed an exophytic growth measuring  cm extending from the mandibular left first premolar to the second molar. The patient underwent a left hemimandibular resection. Histopathological examination revealed a biphasic tumor composed of inconspicuous islands of benign odontogenic epithelium and an abundant malignant mesenchymal component with marked cellularity, nuclear pleomorphism, hyperchromatism, and moderate mitotic figures with clear margins; one year after the surgical procedure, the patient is clinically and radiologically disease-free.