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Case Reports in Pathology
Volume 2015, Article ID 513968, 6 pages
http://dx.doi.org/10.1155/2015/513968
Case Report

Clonal CD8+ T Lymphocytic Proliferation and Karyotypical Abnormalities in an EBV Associated Hemophagocytic Lymphohistiocytosis

1Department of Pathology and Laboratory Medicine, Indiana University, Indianapolis, IN 46202, USA
2Department of Pathology and Laboratory Medicine, Cincinnati Children’s Hospital and Medical Center, Cincinnati, OH 45229, USA

Received 26 June 2015; Accepted 27 August 2015

Academic Editor: Dimosthenis Miliaras

Copyright © 2015 Jiehao Zhou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. J.-I. Henter, M. Arico, G. Elinder, S. Imashuku, and G. Janka, “Familial hemophagocytic lymphohistiocytosis. Primary hemophagocytic lymphohistiocytosis,” Hematology/Oncology Clinics of North America, vol. 12, no. 2, pp. 417–433, 1998. View at Publisher · View at Google Scholar · View at Scopus
  2. S. Imashuku, “Treatment of Epstein-Barr virus-related hemophagocytic lymphohistiocytosis (EBV-HLH); update 2010,” Journal of Pediatric Hematology/Oncology, vol. 33, no. 1, pp. 35–39, 2011. View at Publisher · View at Google Scholar · View at Scopus
  3. L. Quintanilla-Martinez, H. Kimura, and E. S. Jaffe, “EBV-positive T-cell lymphoproliferative disorders of childhood,” in WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues, S. H. Swerdlow, E. Campo, N. L. Harris et al., Eds., pp. 278–280, IARC Press, Lyon, France, 2008. View at Google Scholar
  4. M. C. Smith, D. N. Cohen, B. Greig et al., “The ambiguous boundary between EBV-related hemophagocytic lymphohistiocytosis and systemic EBV-driven T cell lymphoproliferative disorder,” International Journal of Clinical and Experimental Pathology, vol. 7, no. 9, pp. 5738–5749, 2014. View at Google Scholar · View at Scopus
  5. M. F. C. Callan, N. Steven, P. Krausa et al., “Large clonal expansions of CD8+ T cells in acute infectious mononucleosis,” Nature Medicine, vol. 2, no. 8, pp. 906–911, 1996. View at Publisher · View at Google Scholar · View at Scopus
  6. J.-I. Henter, A. Horne, M. Aricó et al., “HLH-2004: diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis,” Pediatric Blood and Cancer, vol. 48, no. 2, pp. 124–131, 2007. View at Publisher · View at Google Scholar · View at Scopus
  7. L. Quintanilla-Martinez, S. Kumar, F. Fend et al., “Fulminant EBV+ T-cell lymphoproliferative disorder following acute/chronic EBV infection: a distinct clinicopathologic syndrome,” Blood, vol. 96, no. 2, pp. 443–451, 2000. View at Google Scholar · View at Scopus
  8. J. Weisberger, D. Cornfield, W. Gorczyca, and Z. Liu, “Down-regulation of pan-T-cell antigens, particularly CD7, in acute infectious mononucleosis,” American Journal of Clinical Pathology, vol. 120, no. 1, pp. 49–55, 2003. View at Publisher · View at Google Scholar · View at Scopus
  9. A. Toga, T. Wada, Y. Sakakibara et al., “Clinical significance of cloned expansion and CD5 down-regulation in epstein-barr virus (EBV) infected CD8+ T lymphocytes in EBV-Associated hemophagocytic lymphohistiocytosis,” Journal of Infectious Diseases, vol. 201, no. 12, pp. 1923–1932, 2010. View at Publisher · View at Google Scholar · View at Scopus
  10. Y. Kaneko, N. Maseki, M. Sakurai et al., “Clonal and non-clonal karyotypically abnormal cells in haemophagocytic lymphohistiocytosis,” British Journal of Haematology, vol. 90, no. 1, pp. 48–55, 1995. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Imashuku, S. Hibi, Y. Tabata et al., “Outcome of clonal hemophagocytic lymphohistiocytosis: analysis of 32 cases,” Leukemia & Lymphoma, vol. 37, no. 5-6, pp. 577–584, 2000. View at Publisher · View at Google Scholar · View at Scopus
  12. J.-S. Chen, C.-C. Tzeng, C.-J. Tsao et al., “Clonal karyotype abnormalities in EBV-associated hemophagocytic syndrome,” Haematologica, vol. 82, no. 5, pp. 572–576, 1997. View at Google Scholar · View at Scopus