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Case Reports in Pathology
Volume 2015, Article ID 537297, 4 pages
Case Report

MYC Amplification in Angiosarcoma Arising from an Arteriovenous Graft Site

1Department of Medicine, Section of Dermatology, University of Chicago, 5841 S Maryland Avenue, MC 5067, Chicago, IL 60637, USA
2Department of Medicine, Section of Hematology/Oncology, University of Chicago, 5841 S Maryland Avenue, MC 6092, Chicago, IL 60637, USA
3Department of Pathology, University of Chicago, 5841 S Maryland Avenue, MC 6161, Chicago, IL 60637, USA

Received 1 August 2015; Revised 29 October 2015; Accepted 8 November 2015

Academic Editor: Khin Thway

Copyright © 2015 Kristen M. Paral et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Angiosarcoma arising in association with an arteriovenous graft (AVG) or fistula is a unique clinicopathologic scenario that appears to be gaining recognition in the literature. Among reported cases, none has described high-level MYC gene amplification, a genetic aberration that is increasingly unifying the various clinicopathologic subdivisions of angiosarcoma. We therefore report the MYC gene status in a case of angiosarcoma arising at an AVG site.