Hepatocellular Carcinoma with Both Fibrolamellar and Classical Components: An Unusual Morphological Pattern

Table 1

Summary of clinical findings of reported cases of coexistent FLC and classical HCC.

Author	Age (years)	Sex	Clinical presentation	Tumor size and lobe	Liver enzymes	AFP	CEA	HBV antigen titers	Non- neoplastic liver	Other findings	Type of tumor
Okada et al. [8]	56	M	Referral	1.9 cm left and 1.8 cm caudate	Elevated	Elevated	WNL	Negative	Cirrhosis	Leukopenia	Synchronous FLC and HCC
Singh and Ramakrishna [9]	14	M	Abdominal pain	10 cm right and 8 cm right	Elevated	WNL	WNL	Negative	None present	None	Synchronous FLC and HCC
Seitz et al. [5]	27	F	Epigastric pain	16 cm right	Elevated	WNL	NA	Negative	None present	None	Mixed FLC and HCC
Reuland et al. [6]	39	F	Incidental finding	NA	WNL	WNL	WNL	NA	None present	Leukocytosis and elevated ESR	Mixed FLC and HCC
Okano et al. [7]	52	M	Incidental finding	3.5 cm left	WNL	Elevated	WNL	Negative	None present	None	Mixed FLC and HCC
Castro-Villabón et al. (present case)	37	F	Abdominal distension and epigastric mass	13 cm left	Elevated	WNL	WNL	Negative	None present	None	Mixed FLC and HCC

AFP: a-fetoprotein; CEA: carcinoembryonic antigen; HBV: hepatitis B virus; ESR: erythrocyte sedimentation rate; WNL: within normal limits; NA: not available.