Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Pathology
Volume 2016, Article ID 1532424, 10 pages
http://dx.doi.org/10.1155/2016/1532424
Case Report

A Biphasic Pleural Tumor with Features of an Epithelioid and Small Cell Mesothelioma: Morphologic and Molecular Findings

Department of Pathology and Anatomical Sciences, University of Missouri, M263 Medical Science Building, One Hospital Drive, Columbia, MO 65212, USA

Received 6 April 2016; Accepted 23 May 2016

Academic Editor: Sonja Klebe

Copyright © 2016 Sarah Hackman et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. F. Galateau-Salle, A. Churg, V. Roggli et al., “Mesothelial tumors, diffuse malignant mesothelioma. Epithelioid mesothelioma,” in WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart, W. D. Travis, E. Brambilla, A. P. Burke, A. Marx, and A. G. Nicholson, Eds., pp. 156–164, International Agency for Research on Cancer, Lyon, France, 4th edition, 2015. View at Google Scholar
  2. D. D. M. Fletcher, S. Dacic, and M. Ladanyi, “Desmoplastic round cell tumor,” in WHO Classification of Tumours of the Lung, Pleura, Thymus and Heart, W. D. Travis, E. Brambilla, A. P. Burke, A. Marx, and A. G. Nicholson, Eds., pp. P180–181, International Agency for Research on Cancer, Lyon, France, 4th edition, 2015. View at Google Scholar
  3. V. Parkash, W. L. Gerald, A. Parma, M. Miettinen, and J. Rosai, “Desmoplastic small round cell tumor of the pleura,” American Journal of Surgical Pathology, vol. 19, no. 6, pp. 659–665, 1995. View at Publisher · View at Google Scholar · View at Scopus
  4. L. P. Dehner, “Pleuropulmonary blastoma is the pulmonary blastoma of childhood,” Seminars in Diagnostic Pathology, vol. 11, no. 2, pp. 144–151, 1994. View at Google Scholar · View at Scopus
  5. F. G. Mayall and A. R. Gibbs, “The histology and immunohistochemistry of small cell mesothelioma,” Histopathology, vol. 20, no. 1, pp. 47–51, 1992. View at Publisher · View at Google Scholar · View at Scopus
  6. N. G. Ordóñez, “Mesotheliomas with small cell features: report of eight cases,” Modern Pathology, vol. 25, no. 5, pp. 689–698, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. Y. J. Cha, B. Kim, J. Han, C. A. Yi, and J. I. Zo, “A rare case of mesothelioma showing micropapillary and small cell differentiation with aggressive behavior,” Korean Journal of Pathology, vol. 48, no. 6, pp. 466–468, 2014. View at Publisher · View at Google Scholar · View at Scopus
  8. J. Rosai, Ackerman's Surgical Pathology, Mosby/Elsevier, Edinburgh, Scotland, 10th edition, 2011.
  9. A. Churg, V. Roggli, F. Galateau-Salle et al., “Mesothlioma,” in World Health Organization Classification of Tumours. Pathology and Genetics. Tumors of the Lung, Pleura, Thymus and Heart, W. D. Travis, E. Brambilla, H. K. Müller-Hermelink, and CC. Harris, Eds., pp. 128–140, IARC Press, Lyon, France, 2004. View at Google Scholar
  10. W. L. Gerald, H. K. Miller, H. Battifora, M. Miettinen, E. G. Silva, and J. Rosai, “Intra-abdominal desmoplastic small round-cell tumor: report of 19 cases of a distinctive type of high-grade polyphenotypic malignancy affecting young individuals,” American Journal of Surgical Pathology, vol. 15, no. 6, pp. 499–513, 1991. View at Publisher · View at Google Scholar · View at Scopus
  11. L. J. Layfield and C. Lenarsky, “Desmoplastic small cell tumors of the peritoneum coexpressing mesenchymal and epithelial markers,” American Journal of Clinical Pathology, vol. 96, no. 4, pp. 536–543, 1991. View at Publisher · View at Google Scholar · View at Scopus
  12. A. N. Wolf, M. Ladanyi, G. Paull, J. E. Blaugrund, and W. H. Westra, “The expanding clinical spectrum of desmoplastic small round-cell tumor: a report of two cases with molecular confirmation,” Human Pathology, vol. 30, no. 4, pp. 430–435, 1999. View at Publisher · View at Google Scholar · View at Scopus
  13. F. Chang, “Desmoplastic small round cell tumors: cytologic, histologic, and immunohistochemical features,” Archives of Pathology and Laboratory Medicine, vol. 130, no. 5, pp. 728–732, 2006. View at Google Scholar · View at Scopus
  14. B. Rekhi, S. Ahmed, R. Basak et al., “Desmoplastic small round cell tumor-clinicopathological spectrum, including unusual features and immunohistochemical analysis of 45 tumors diagnosed at a tertiary cancer referral centre, with molecular results t(11; 22) (p13; q12) (EWS-WT1) in select cases,” Pathology and Oncology Research, vol. 18, no. 4, pp. 917–927, 2012. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Li, M.-Y. Cai, J.-B. Lu, J.-H. Hou, Q.-L. Wu, and R.-Z. Luo, “Clinicopathological investigation of four cases of desmoplastic small round cell tumor,” Oncology Letters, vol. 4, no. 3, pp. 423–428, 2012. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Liang, “Desmoplastic small round cell tumor with atypical immunohistochemical profile and rhabdoid-like differentiation,” World Journal of Clinical Cases, vol. 2, no. 8, p. 367, 2014. View at Publisher · View at Google Scholar
  17. J. Nakayama, S. Nassau, K. Atkins, and S. C. Modesitt, “Desmoplastic small round cell tumor of the ovary: a rare but devastating disease in young women,” Gynecologic Oncology Case Reports, vol. 7, pp. 16–18, 2014. View at Publisher · View at Google Scholar · View at Scopus
  18. M. E. Lae, P. C. Roche, L. Jin, R. V. Lloyd, and A. G. Nascimento, “Desmoplastic small round cell tumor: a clinicopathologic, immunohistochemical, and molecular study of 32 tumors,” The American Journal of Surgical Pathology, vol. 26, no. 7, pp. 823–835, 2002. View at Publisher · View at Google Scholar · View at Scopus
  19. E. Rodriguez, C. Sreekantaiah, W. Gerald, V. E. Reuter, R. J. Motzer, and R. S. K. Chaganti, “A recurring translocation, t(11;22)(p13;q11.2), characterizes intra-abdominal desmoplastic small round-cell tumors,” Cancer Genetics and Cytogenetics, vol. 69, no. 1, pp. 17–21, 1993. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Ladanyi and W. Gerald, “Fusion of the EWS and WT1 genes in the desmoplastic small round cell tumor,” Cancer Research, vol. 54, no. 11, pp. 2837–2840, 1994. View at Google Scholar · View at Scopus
  21. A. J. Murphy, K. Bishop, C. Pereira et al., “A new molecular variant of desmoplastic small round cell tumor: significance of WT1 immunostaining in this entity,” Human Pathology, vol. 39, no. 12, pp. 1763–1770, 2008. View at Publisher · View at Google Scholar · View at Scopus
  22. P. J. Zhang, J. R. Goldblum, B. R. Pawel, C. Fisher, T. L. Pasha, and F. G. Barr, “Immunophenotype of desmoplastic small round cell tumors as detected in cases with EWS-WT1 gene fusion product,” Modern Pathology, vol. 16, no. 3, pp. 229–235, 2003. View at Publisher · View at Google Scholar · View at Scopus
  23. N. Raizada, M. K. Daga, N. Sinha et al., “A rapidly developing lung mass diagnosed as desmoplastic small round cell tumor,” Lung India, vol. 28, no. 4, pp. 287–290, 2011. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Yaziji, H. Battifora, T. S. Barry et al., “Evaluation of 12 antibodies for distinguishing epithelioid mesothelioma from adenocarcinoma: identification of a three-antibody immunohistochemical panel with maximal sensitivity and specificity,” Modern Pathology, vol. 19, no. 4, pp. 514–523, 2006. View at Publisher · View at Google Scholar · View at Scopus
  25. M. S. Waugh, R. C. Dash, K. C. Turner, and L. G. Dodd, “Desmoplastic small round cell tumor: using FISH as an ancillary technique to support cytologic diagnosis in an unusual case,” Diagnostic Cytopathology, vol. 35, no. 8, pp. 516–520, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. P. Angunawela, A. A. Khalafallah, K. Wolfswinkel, D. Seaton, and T. Brain, “An unusual presentation of desmoplastic small round cell tumour of the abdomen: morphological, immunohistochemical, ultrastructural, and molecular studies,” Case Reports in Oncological Medicine, vol. 2011, Article ID 183938, 4 pages, 2011. View at Publisher · View at Google Scholar
  27. R. La Starza, G. Barba, V. Nofrini et al., “Multiple EWSR1-WT1 and WT1-EWSR1 copies in two cases of desmoplastic round cell tumor,” Cancer Genetics, vol. 206, no. 11, pp. 387–392, 2013. View at Publisher · View at Google Scholar · View at Scopus
  28. H. Werner, G. Idelman, M. Rubinstein, P. Pattee, S. R. Nagalla, and C. T. Roberts Jr., “A novel EWS-WT1 gene fusion product in desmoplastic small round cell tumor is a potent transactivator of the insulin-like growth factor-I receptor (IGF-IR) gene,” Cancer Letters, vol. 247, no. 1-2, pp. 84–90, 2007. View at Publisher · View at Google Scholar · View at Scopus
  29. W. L. Gerald and D. A. Haber, “The EWS-WT1 gene fusion in desmoplastic small round cell tumor,” Seminars in Cancer Biology, vol. 15, no. 3, pp. 197–205, 2005. View at Publisher · View at Google Scholar · View at Scopus
  30. J. Liu, M. M. Nau, J. C. Yeh, C. J. Allegra, E. Chu, and J. J. Wright, “Molecular heterogeneity and function of EWS-WT1 fusion transcripts in desmoplastic small round cell tumors,” Clinical Cancer Research, vol. 6, no. 9, pp. 3522–3529, 2000. View at Google Scholar · View at Scopus
  31. J. Kim, K. Lee, and J. Pelletier, “The desmoplastic small round cell tumor t(11;22) translocation produces EWS/WT1 isoforms with differing oncogenic properties,” Oncogene, vol. 16, no. 15, pp. 1973–1979, 1998. View at Publisher · View at Google Scholar · View at Scopus
  32. P. Bandopadhayay, A. M. Jabbour, C. Riffkin et al., “The oncogenic properties of EWS/WT1 of desmoplastic small round cell tumors are unmasked by loss of p53 in murine embryonic fibroblasts,” BMC Cancer, vol. 13, article no. 585, 2013. View at Publisher · View at Google Scholar · View at Scopus
  33. E. de Alava, M. Ladanyi, J. Rosai, and W. L. Gerald, “Detection of chimeric transcripts in desmoplastic small round cell tumor and related developmental tumors by reverse transcriptase polymerase chain reaction: a specific diagnostic assay,” American Journal of Pathology, vol. 147, no. 6, pp. 1584–1591, 1995. View at Google Scholar · View at Scopus
  34. G. Klorin, E. Rozenblum, O. Glebov et al., “Integrated high-resolution array CGH and SKY analysis of homozygous deletions and other genomic alterations present in malignant mesothelioma cell lines,” Cancer Genetics, vol. 206, no. 5, pp. 191–205, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. N. M. Granja, M. D. Begnami, J. Bortolan, A. L. Filho, and F. C. Schmitt, “Desmoplastic small round cell tumour: cytological and immunocytochemical features,” CytoJournal, vol. 2, article 6, 2005. View at Publisher · View at Google Scholar · View at Scopus