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Case Reports in Pathology
Volume 2016, Article ID 1738696, 3 pages
Case Report

From the Gut to the Liver: Another Organ to Watch in FAP Patients

1Department of Pathology, University of Arizona, Tucson, AZ 85724, USA
2Section of Hematology and Oncology, University of Arizona, Tucson, AZ 85724, USA

Received 15 December 2015; Revised 28 February 2016; Accepted 8 March 2016

Academic Editor: Janina Kulka

Copyright © 2016 Spencer Paulson et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We report a rare association of hepatocellular carcinoma with familial adenomatous polyposis in a young patient and its clinical significance. A 28-year-old female with a past medical history of familial adenomatous polyposis (FAP) and subsequent colonic adenocarcinoma underwent total colectomy. She later presented with intermittent right upper quadrant pain and nausea of four months’ duration. MRI of the abdomen revealed multiple liver lesions, the largest 8.5 cm in diameter, with radiologic features suggestive of hepatocellular carcinoma. A CT-guided liver biopsy demonstrated well-differentiated HCC which was confirmed by immunohistochemistry. In patients with a history of FAP, a heightened awareness of the possibility of concurrent or subsequent HCC is warranted.