Table of Contents Author Guidelines Submit a Manuscript
Case Reports in Pathology
Volume 2016, Article ID 3534791, 5 pages
Case Report

Spinal Intradural, Extramedullary Ependymoma with Astrocytoma Component: A Case Report and Review of the Literature

1Department of Radiology, Tufts Medical Center, Boston, MA, USA
2Department of Pathology and Laboratory Medicine, Tufts Medical Center, Boston, MA, USA
3Department of Neurosurgery, Tufts Medical Center, Boston, MA, USA
4Department of Radiology, Massachusetts General Hospital, Boston, MA, USA

Received 27 February 2016; Accepted 10 April 2016

Academic Editor: Yoji Nagashima

Copyright © 2016 Gene M. Weinstein et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Ependymomas are common spinal lesions, with the vast majority arising in an intramedullary location. Several cases have been described in the literature of ependymomas in an intradural, extramedullary location. The authors present a case of a 56-year-old female who presented with several weeks of lower back pain and weakness. MRI revealed an intradural, extramedullary enhancing mass at L1-L2. The mass was successfully resected surgically. Pathologic evaluation revealed a low grade glioma with components of both ependymoma and pilocytic astrocytoma with MUTYH G382D mutation. Extramedullary ependymomas are very rare tumors. To the authors’ knowledge, this is the first case of ependymoma/astrocytoma collision tumors described in an extramedullary location.