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Case Reports in Pathology
Volume 2016, Article ID 5160180, 5 pages
http://dx.doi.org/10.1155/2016/5160180
Case Report

Lobular Carcinoma of the Breast Metastatic to the Spleen and Accessory Spleen: Report of a Case

The Institute of Pathology, Hillel Yaffe Medical Center, Hadera, Israel

Received 31 May 2016; Accepted 21 August 2016

Academic Editor: Janina Kulka

Copyright © 2016 Gabriel M. Groisman. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Despite the fact that accessory spleen (also known as supernumerary spleen, splenunculus, or splenule) can be found in 10–30% of patients undergoing autopsies, metastatic disease occurring in this organ has been barely reported. A case of lobular breast carcinoma metastatic to the spleen and accessory spleen found incidentally at therapeutic splenectomy for severe anemia and thrombocytopenia is described. On microscopic examination both organs revealed severe fibrocongestive changes and extramedullary hematopoiesis with no obvious carcinomatous involvement. Cytokeratin 7, estrogen receptors, and GATA3 immunohistochemistry disclosed the presence of numerous metastatic breast carcinoma cells infiltrating the splenic parenchyma. This case demonstrates that metastatic carcinoma can be encountered, although rarely, in accessory spleens and that cytokeratin stain should be performed in sections of spleens and/or accessory spleens excised from cancer patients in which the presence of malignant epithelial cells is not recognized on routine sections.