Lobular Carcinoma of the Breast Metastatic to the Spleen and Accessory Spleen: Report of a Case

Figure 2

(a) Low power microscopic view of the accessory spleen showing marked congestion and a nodular pattern (hematoxylin and eosin stained section, magnification 20). (b) High power view shows extramedullary hematopoiesis including atypical megakaryocytes (hematoxylin and eosin stained section, magnification 400). (c) Small cells with occasional cytoplasmic vacuoles resembling lobular carcinoma cells infiltrate the fatty tissue (hematoxylin and eosin stained section, magnification 400). (d) Cytokeratin stain highlights numerous cells that represent metastatic carcinoma (magnification 100). (e) Estrogen receptors and (f) GATA3 strongly stain the nuclei of the cancer cells confirming the mammary origin of the cancer ((e) and (f) magnification 200).

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