Langerhans Cell Histiocytosis: A Diagnostic Challenge in the Oral Cavity

Figure 2

Infiltration of the edematous stroma by polygonal cells with eosinophilic cytoplasm, oval nuclei with longitudinal grooves resembling coffee beans named as Langerhans cells, and eosinophils are observed. (a) Haematoxylin and eosin, ×200 magnification. (b) Haematoxylin and eosin, ×400 magnification. (c) Langerhans cells were highlighted immunohistochemically by S-100, ×200 magnification. (d) Langerhans cells were highlighted immunohistochemically by CD1a, ×200 magnification.

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