Case Report
Diffuse Alveolar Hemorrhage in Systemic Lupus Erythematosus: Histopathologic Features and Clinical Correlations
Table 1
Selected differential diagnoses of the three histologic patterns of diffuse alveolar hemorrhage (after Park [
1]).
| Histologic patterns | Diseases |
| Capillaritis | |
| Systemic vasculitides | Behçet’s syndrome | Cryoglobulinemia | Granulomatosis with polyangiitis | Henoch- Schönlein purpura |
| Rheumatic diseases | Rheumatoid arthritis | Systemic lupus erythematosus | Antiphospholipid antibodies |
| Drugs | Hydralazine | TNF-alpha antagonists |
| Bland hemorrhage | |
| Connective tissue disease | Goodpasture disease | Systemic lupus erythematosus |
| Drugs | Anticoagulant therapy | Platelet glycoprotein IIB/IIIA inhibitors |
| Diffuse alveolar damage | |
| Infection | Infection leading to ARDS (viral, bacterial) | Opportunistic infections in compromised host |
| Rheumatic diseases | Polymyositis | Systemic lupus erythematosus |
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