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Case Reports in Pathology
Volume 2017, Article ID 2753487, 5 pages
Case Report

Cyanoacrylate Associated Foreign Body Granulomatous Gastritis: A Report of Three Cases

1Department of Pathology, Faculty of Medicine, Hacettepe University, Sıhhiye, 06100 Ankara, Turkey
2Gastroenterology Division, Department of Internal Medicine, Faculty of Medicine, Hacettepe University, Sıhhiye, 06100 Ankara, Turkey

Correspondence should be addressed to Aytekin Akyol; moc.liamg@niketya.loyka

Received 22 October 2016; Accepted 21 December 2016; Published 19 January 2017

Academic Editor: Adriana Handra-Luca

Copyright © 2017 Gunes Guner et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Granulomas are rarely seen in gastric biopsies mostly as an involvement of granulomatous diseases like sarcoidosis, Crohn’s disease, infections, neoplasms, and vasculitis. Here, we claim cyanoacrylate as a foreign body type granuloma-causing agent in the stomach after vascular embolisation. We present cyanoacrylate associated gastric changes of three cases: two endoscopic biopsies and one gastric resection. In two cases, cyanoacrylate associated ulcers and granulomatous inflammation were observed in gastric mucosal biopsies following endoscopic examination after 7 months and 6 years of the glue injections, respectively. In the third case, the cyanoacrylate injection was performed 2 months prior to the surgery. Then the patient underwent distal pancreatectomy for pancreatic adenocarcinoma and during the operation a gastric mass was resected with a suspicion of tumoral infiltration. These three cases demonstrated that glue exposure causes active chronic inflammation with foreign body type granulomas, mucosal ulceration, and bleeding in the gastric mucosa. Even further, it can induce mass formation in the injection sites.