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Case Reports in Pathology
Volume 2017, Article ID 4541620, 5 pages
Case Report

Calciphylaxis of the Postmenopausal Female Breast: An Uncommonly Encountered Mimic of Carcinoma

1Robert J. Tomsich Pathology and Laboratory Medicine Institute, Cleveland Clinic, Cleveland, OH 44195, USA
2Surgery Institute, Breast Cancer Surgery, Cleveland Clinic, Cleveland, OH 44195, USA
3Imaging Institute, Diagnostic Radiology, Breast Imaging, Cleveland Clinic, Cleveland, OH 44195, USA

Correspondence should be addressed to Charles D. Sturgis; gro.fcc@cigruts

Received 24 May 2017; Accepted 10 July 2017; Published 9 August 2017

Academic Editor: Sami Shousha

Copyright © 2017 Aaron G. Novotny et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Calciphylaxis is a serious medical condition that is typically associated with end-stage renal disease and presents as the sequelae of calcifications in arterioles with subsequent ischemia of affected tissues. Classically, calciphylaxis produces ulcerated and necrotic skin lesions. These may be biopsied to aid in confirmation of the diagnosis. Herein we report a case of a large necrotic breast lesion in the clinical setting of calciphylaxis, and we emphasize that a multidisciplinary approach to diagnosis and management is important to avoid unnecessary oncological resection.