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Case Reports in Pathology
Volume 2017 (2017), Article ID 4846018, 5 pages
Case Report

Plasmacytoma as a Mimicker of Colonic Carcinoma in an Elderly Man

Department of Pathology, Salmaniya Medical Center, P.O. Box 12, Manama, Bahrain

Correspondence should be addressed to Sara Mathew George

Received 23 November 2016; Accepted 6 April 2017; Published 19 April 2017

Academic Editor: Hiroko Kuwabara

Copyright © 2017 Sara Mathew George et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Multiple myeloma is a neoplastic proliferation of monoclonal plasma cells. Although it is usually restricted to the bone marrow, extraskeletal spread in the form of localised extramedullary collections of malignant plasma cells (plasmacytomas) can occur. However, gastrointestinal tract involvement in multiple myeloma is rare and overt gastrointestinal bleeding from plasmacytoma is uncommon. We report a case of colonic plasmacytoma which presented with bleeding per rectum and was initially misdiagnosed as colonic neuroendocrine carcinoma. Later the patient presented with recurrence of the colonic mass along with multiple lytic bone lesions. The diagnosis of colonic plasmacytoma with progression into multiple myeloma was given. We also discuss here the diagnostic difficulty of plasma cell neoplasms in small biopsies of the colon.