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Case Reports in Pathology
Volume 2017 (2017), Article ID 5981013, 4 pages
Case Report

Nodular Lymphocyte Predominant Hodgkin Lymphoma of the Ileum

1Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN, USA
2Colon and Rectal Surgery Associates, Burnsville, MN, USA

Correspondence should be addressed to Andrew L. Feldman

Received 5 July 2017; Accepted 10 October 2017; Published 2 November 2017

Academic Editor: Stefan Pambuccian

Copyright © 2017 Aruna Rangan et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare lymphoma derived from germinal center B lymphocytes that typically presents with localized lymph node involvement and can mimic a variety of both reactive and other neoplastic conditions. Extranodal involvement is uncommon in NLPHL and typically occurs in the context of previously documented or synchronous nodal disease. Involvement of the gastrointestinal tract is exceedingly rare. Here, we present the first case to our knowledge of NLPHL involving the ileum that was discovered incidentally on routine screening colonoscopy in an asymptomatic patient. An awareness of the spectrum of clinical presentations, careful morphologic evaluation, and a comprehensive panel of immunohistochemical stains are essential for correct diagnosis of NLPHL presenting in unusual anatomic sites.